How fast it swelled is the first clueEmerging evidence
After an injury, a clinical review says swelling within minutes to a few hours usually points to bleeding inside the joint, from a torn ligament, a break inside the joint or a dislocated kneecap, while swelling that builds over hours to a few days usually points to a meniscus tear. Without an injury, swelling with redness or warmth points to gout, pseudogout, an arthritis flare or infection, and swelling limited to the kneecap points to bursitis.
In 1,145 knees in Sweden that bled into the joint after an injury, a magnetic resonance imaging (MRI) scan found a torn anterior cruciate ligament (ACL) in 52%, a meniscus tear in 41% and a dislocated kneecap in 17%. Only 12% of the ACL tears were the only injury, and at 16 and under a dislocated kneecap was the commonest. Most of the injuries (72%) happened in sport.
Sources 1, 2
A hot, swollen knee: infection, gout or pseudogoutStrong evidence
A joint infection (septic arthritis) causes sudden severe pain, usually in one joint, with swelling, a change in skin colour and difficulty moving it, often with a high temperature or feeling unwell. The NHS says it needs urgent help, and most people are treated in hospital. It's more likely with older age, diabetes, rheumatoid arthritis, recent joint surgery, a knee or hip replacement, a skin infection, a weakened immune system or human immunodeficiency virus (HIV). In 14 studies of 6,242 people, joint pain (85%), a history of swelling (78%) and fever (57%) were the only features found in more than half of those with an infected joint, so no single sign rules it out.
Gout can affect the knee, and the National Institute for Health and Care Excellence (NICE) asks clinicians to think of it when severe pain, redness or swelling comes on quickly, often overnight. Acute calcium pyrophosphate (CPP) crystal arthritis, once called pseudogout, is rare under 60, and the knee is the joint it affects most often, Arthritis UK says. European recommendations say it is confirmed by finding the crystals in fluid from the joint, which is also how an infection is found.
Sources 3, 4, 5, 6, 7, 8
Other causes: arthritis, bursitis, a Baker's cyst and blood thinnersStrong evidence
The NHS lists mild swelling with pain and stiffness, often in both knees and more common in older people, under osteoarthritis, and warm, red swelling made worse by kneeling or bending under bursitis. It lists swelling, warmth and bruising, more likely while taking a blood thinner (anticoagulant), as bleeding into the joint. Rheumatoid arthritis causes pain, swelling and stiffness, often on both sides, with morning stiffness that lasts longer than the 30 minutes or so usual in osteoarthritis (an NHS page past its review date).
Bursitis on the kneecap usually follows kneeling or a blow, the American Academy of Orthopaedic Surgeons (AAOS) says. A Baker's cyst is a soft lump behind the knee, more visible when you stand, more common between 35 and 70 and, in adults, usually caused by another knee problem, such as an injury, arthritis or gout.
Sources 9, 10, 11, 12, 13
Why the thigh switches offEmerging evidence
Fluid in the knee reduces the activity of the thigh muscle. In an experiment in 10 healthy volunteers, 20 to 30 millilitres of fluid in the knee was enough to switch off part of the inner thigh muscle, and the effect went when the joint was numbed. A review calls this arthrogenic muscle inhibition and describes it as a lasting barrier to rehabilitation after injury, surgery and in arthritis. That's why this guide starts thigh tightening and heel slides early, though no trial has tested that order in a swollen knee.
Sources 14, 15
When a test or a scan helpsStrong evidence
Fluid drawn from the knee with a needle is the test that finds an infection or crystals: the white cell count in it changes the likelihood of infection before the culture is back, and crystals confirm CPP crystal disease. NICE suggests it when gout is uncertain, with imaging if it can't be done.
After an injury, the Ottawa knee rule decides whether you need an X-ray (across 6 studies of 4,249 adults it picked up 98.5% of breaks), and an MRI scan follows when a ligament, meniscus or kneecap injury may need surgery. A suspected clot needs an ultrasound scan: NICE aims for the result within 4 hours if possible, and the NHS says you should be referred within 24 hours.
Sources 4, 8, 5, 16, 2, 17, 18
How long it lastsEmerging evidence
It depends on the cause. A gout attack usually lasts 1 to 2 weeks untreated (an NHS page past its review date). An attack of CPP crystal arthritis lasts several days to 2 weeks, with the swelling going down within a week and the joint back to normal in 2 to 3 weeks, Arthritis UK says. Bursitis that isn't infected usually settles in a few weeks; a Baker's cyst can take months to a few years to go, and a burst one a few weeks to settle. An infected joint needs about 2 weeks in hospital on average.
After an injury, it depends on what was hurt. In one trial, fluid that was drained came back within a week. No one can promise a date.
Sources 6, 7, 11, 13, 3, 19