Walking, balance and transfersEmerging evidence
A review of 23 studies (408 adults living at home) found the best evidence for programmes that mix aerobic exercise with strength or balance work. With moderate confidence, 1 to 3 sessions a week of 20 to 60 minutes improved balance, walking speed, how far people could walk, and transfers. Evidence on fitness, strength and flexibility on their own was weak, because there were few studies.
Source 5
Walking speed and distanceEmerging evidence
In 16 randomised trials, exercise improved walking a little in the first months after an amputation and moderately later on. Another review pooled 7 trials: the distance people walked in 2 minutes rose by about 9 metres, and a timed test of standing up, walking and sitting down got about 2 seconds quicker. The studies were small and varied.
Sources 6, 19
Walking practice and strength trainingEmerging evidence
In 8 low-quality studies, walking practice with resistance or everyday tasks improved walking speed more than supervised walking alone. Strength training combined with other exercise improved strength, balance and walking, though the trials can't separate the strength work from the rest.
Sources 20, 21
FallsEmerging evidence
In a very small trial (15 people), 12 weeks of strength, balance, flexibility and walking exercise was followed by fewer falls over the next year, and walking became about 0.2 metres a second faster. Falls guidance for amputees, mostly drawn from research in older people, recommends combining balance, strength and endurance exercise.
Sources 22, 7
Quality of lifeMixed evidence
Pooling 3 studies, organised activity programmes didn't clearly improve quality of life, and their effect on phantom pain is unclear, because there wasn't enough data to pool.
Source 11
Heart risk after an amputationEmerging evidence
In 22,950 people in South Korea with an amputation after an injury, heart attacks (1.30 times as likely), heart failure (1.27 times) and an irregular heartbeat (1.17 times) were more common than in matched people without one. UK veterans with combat amputations had more insulin resistance, inflammation and fat around the organs than both injured veterans without an amputation and uninjured veterans. In Sweden, people with type 2 diabetes who had an amputation had 2.46 times the risk of dying of those without, and more than 3 times in the first year. These are observational studies, so they show links, not causes.
Sources 8, 23, 9
Your other knee and hipMixed evidence
Studies disagree. In US veterans, knee pain in the other leg was 3.3 times as common after an above-knee amputation, but not clearly raised after a below-knee one. In 78 Dutch people with an amputation after an injury, 27% had knee and 14% hip osteoarthritis. Yet a database study of 1,569 people with an above-knee amputation found less osteoarthritis than in matched people without one.
Sources 24, 25, 26
Back painMixed evidence
Low back pain is common, about 62% across 51 studies, and more common after the amputation than before; frequent back pain goes with more disability. Only 2 studies have tested exercise for it.
Sources 17, 27, 28
Treatments for phantom painMixed evidence
Mirror therapy reduced phantom pain in the first month across 10 trials, but a review of only the trials with a placebo comparison found no clear benefit. Graded motor imagery may help, with very low certainty. In one trial of 51 people, 8 sessions of relaxation, mental imagery and phantom limb exercises reduced phantom pain a month later, compared with physiotherapy for the residual limb. High-quality trials are scarce.
Sources 29, 30, 31, 32, 33