Carpal tunnel syndrome: about twice as common in women, peaking in midlifeStrong evidence
In UK general practice, new carpal tunnel syndrome was diagnosed in about 193 women and 88 men per 100,000 a year, peaking in women at 45 to 54 and in men at 75 to 84; the gap between women and men has narrowed over 20 years. In an Italian area, where nerve tests confirmed it, 80% of cases were women.
It causes tingling or numbness in the thumb, index, middle and part of the ring finger, pain in the wrist or hand, and later a weak grip, worse at night and eased by shaking or rubbing the hand. The NHS lists being overweight, pregnancy, repetitive bending or forceful gripping, arthritis or diabetes, a family history and a past wrist injury as risks; NHS inform adds the menopause and thyroid problems.
Sources 1, 2, 3, 4, 5, 6
The menopause and HRT: linked, but not shown to cause itEmerging evidence
NHS inform lists the menopause as a carpal tunnel risk factor, and women's carpal tunnel peaks at the usual age of the menopause. But no study has measured carpal tunnel across the menopause, so the link is timing, not proof.
HRT showed no clear link either way: across 7 studies of 270,764 women after the menopause, the odds were not significantly higher, and the only randomised data suggested lower odds. The evidence is mixed.
Sources 5, 1, 7
Not all tingling is carpal tunnelStrong evidence
In 2,466 Swedish adults, 14.4% had tingling in the carpal tunnel's area of the hand, but only 3.8% had clinically certain carpal tunnel syndrome. The NHS lists sprains and breaks, De Quervain's, arthritis, carpal tunnel and ganglions as causes of wrist pain and says "Do not try to diagnose the cause of the pain yourself". Problems in the neck can be felt in the wrist and hand, "even when you don't feel pain in your neck", NHS inform says.
Sources 8, 9, 10
De Quervain's: several times more common in women, and after a birthStrong evidence
In US records, women were diagnosed 2.6 to 4.7 times as often as men, most often at 40 to 59. In the year after giving birth, 0.7% of 357,534 US women were diagnosed with it, against 0.2% of similar women who hadn't given birth.
"Mothers of small babies seem particularly prone to it, but whether this is due to hormonal changes after pregnancy or due to lifting the baby repeatedly is not known", UK hand surgeons say. It hurts on the thumb side of the wrist when you lift with your thumbs up, grip, wring or use scissors.
Sources 11, 12, 13, 14, 15
Thumb base and hand osteoarthritis: more common in women, from about 50Strong evidence
In 3,595 Finnish adults, thumb base arthritis showed on X-ray in 15% of women and 7% of men. In UK adults aged 50 and over in the community, 22.4% had painful thumb base arthritis, the commonest type, and every type of hand osteoarthritis was more common in women. Women's risk of hand osteoarthritis rises most around the menopause.
X-ray changes are common without pain: they show in "about 25% of women over the age of 55, but many people with arthritis of this joint have no significant pain", UK hand surgeons say.
Sources 16, 17, 18, 19
A broken wrist after a fall: commoner in women, and a sign to check your bonesStrong evidence
From age 35, women broke the wrist about 4 times as often as men (36.8 against 9.0 per 10,000 a year in six UK areas), rising from the perimenopause. Most breaks in later life follow a fall from standing height, and "A fragility fracture is often the first sign that a person has weak bones", the American Academy of Orthopaedic Surgeons (AAOS) says.
Later fractures are common after a broken forearm (55% within 10 years in one US cohort), and fracture risk is about doubled after a previous fracture, highest in the first 2 years. The National Institute for Health and Care Excellence (NICE) counts the wrist as a "major osteoporotic fracture", asks for a fracture risk assessment for everyone 50 and over, and women past the menopause, who have had a fragility fracture, and offers a bone density scan after one in the last 2 years. Osteoporosis "is not usually painful until a bone is broken", the NHS says.
Sources 20, 21, 22, 23, 24, 25, 26
Ganglions and rheumatoid arthritisStrong evidence
Ganglions are "much more common in women than in men" and "are harmless and can safely be left alone", UK hand surgeons say. Rheumatoid arthritis is about twice as common in women (0.93% against 0.40% of UK adults); it "usually affects the hands, feet and wrists", often on both sides, with morning stiffness that often lasts longer than 30 minutes. NICE asks for urgent referral when the small joints of the hands or feet, or more than one joint, are affected, even if blood tests are normal.
Sources 27, 28, 29, 30, 31
Pregnancy and new parenthoodStrong evidence
About 1 in 3 pregnant women (34% of 639 in one study) report carpal tunnel symptoms, mostly after 32 weeks, and they usually settle in the weeks to months after the birth, though in clinic samples more than half still had symptoms at a year. Diagnosed carpal tunnel wasn't more common in the year after the birth; De Quervain's was. Our wrist pain in pregnancy guide covers both.
Sources 32, 33, 13, 34, 6
When a scan or test helpsStrong evidence
Carpal tunnel is diagnosed by "asking about your symptoms and checking your hand"; nerve tests "are not essential" but help when the diagnosis is uncertain, with diabetes or nerve damage, when another nerve may be involved, or for symptoms that come back after surgery, and the UK pathway asks clinicians to check for diabetes and an underactive thyroid. De Quervain's needs no scan, and thumb and hand osteoarthritis are diagnosed without an X-ray at 45 and over when they fit the usual pattern.
After a fall, an X-ray looks for a break, with follow-up for the scaphoid. After a fragility fracture, a fracture risk assessment and a bone density (DXA) scan. For suspected rheumatoid arthritis, referral shouldn't wait for blood tests.
Sources 6, 5, 35, 36, 37, 24, 31
How it usually goesEmerging evidence
Carpal tunnel "sometimes gets better by itself in a few months, particularly if you have it because you're pregnant". De Quervain's "gets better on its own, but may take several weeks or months to settle", an NHS Scotland leaflet says. In thumb and hand arthritis, average pain changes little over 10 years, though some people's hand function worsens, and the symptoms "often stabilise over the long term". Ganglions usually go in "several months up to a year", and a broken wrist takes "around 6 to 12 weeks to recover". No one can promise a timescale.
Sources 6, 14, 38, 19, 39, 27, 40